Molecular assessment of colorectal cancer through Lynch syndrome screening
نویسندگان
چکیده
منابع مشابه
Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics.
BACKGROUND Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance. In particular, patients with Lynch syndrome, hereditary nonpolyposis colorectal cancer (HNPCC), have an...
متن کاملHereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome.
BACKGROUND Hereditary nonpolyposis colorectal cancer HNPCC, Lynch syndrome) is a genetic disease of autosomal dominant inheritance. It is caused by a mutation in one of four genes of the DNA mismatch repair system and confers a markedly increased risk for various types of cancer, particularly of the colon and the endometrium. Its prevalence in the general population is about 1 in 500, and it ca...
متن کاملHereditary colorectal cancer and Lynch syndrome
The term Hereditary Nonpolyposis Colorectal Cancer, or HNPCC, has been less used for naming the classical autosomal dominantly inherited susceptibility to cancer [1]. As this susceptibility applies to tumors from different primary sites other than but including colorectal cancer (CRC), the term Lynch Syndrome (LS) is a less restrictive name. Lynch Syndrome is characterized by an autosomal domin...
متن کاملComment on: Screening for Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) among Endometrial Cancer Patients.
This correspondence is an addendum to our recent report (1) about the prevalence of Lynch syndrome among all newly diagnosed endometrial cancer patients. Two additional deleterious MSH6 gene mutations were found on completion of molecular analysis in the last 19 patients. In addition, RNA studies have allowed the reclassification of one of the presumptive missense mutations c.1304T>C (p.Leu435P...
متن کاملScreening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients.
Endometrial cancer is the most common cancer in women with Lynch syndrome. The identification of individuals with Lynch syndrome is desirable because they can benefit from increased cancer surveillance. The purpose of this study was to determine the feasibility and desirability of molecular screening for Lynch syndrome in all endometrial cancer patients. Unselected endometrial cancer patients (...
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ژورنال
عنوان ژورنال: Diagnostic Histopathology
سال: 2020
ISSN: 1756-2317
DOI: 10.1016/j.mpdhp.2019.10.012